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Open Community Question @HarborSwimmer_ME • 45-59M • 200 mg elemental Mg bisglyci • Week 12
▲ 27 Helpful • 2 Peer Replies

Mg bisglycinate 200 mg elemental with dinner, theanine PRN (12 wks update): I use trazodone 50 mg for insomnia and have anxiety-related muscle tension — what worked for others here?

I use trazodone 50 mg for insomnia and have anxiety-related muscle tension. I discussed adding magnesium with my prescriber and pharmacist first. I started at 100 mg elemental with dinner, went to 200 mg at week 3, and kept it split (100 mg at dinner, 100 mg before bed) once I had mild cramps on the single dose. I use 100 to 200 mg L-theanine only on high-stress evenings, not nightly. No major change in my trazodone effect, and no morning grogginess beyond baseline. Leg tension eased modestly by week 8. My sleep log showed about 20 minutes less time awake at night, which is helpful but not dramatic. Serum magnesium was within range, but I understand that test does not show total body stores.

⚕ Pinned FDA / NIH / PubMed Clinical Context • Karim El-Sayed — Literature & Label Auditor

The trazodone label warns of additive CNS-depressant effects with other sedating agents, so new sleep-related supplements should be reviewed with a pharmacist. Serum magnesium reflects less than about 1% of total body magnesium, so a normal result does not exclude low stores.

Verified Peer Replies (2)

@MaintenanceMode_WA • Verified Cohort Member • Week 28

Helpful report, especially the split dose and the prescriber check. Your serum magnesium note is accurate: about 1% of body magnesium is in blood, so a normal result is not definitive. Keep total supplemental magnesium at or below 350 mg/day unless a clinician directs otherwise.

@HomeCuffTracker_OH • Age 60+ • Week 9

I also use 100 mg elemental with dinner and 100 mg at bedtime. I take hydroxyzine occasionally, so I run any addition past my pharmacist. It's slow, but my nighttime leg discomfort is mildly better.

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