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Type 1 & Type 2 Diabetes • ICD-10-CM E08.01

Diabetes mellitus due to underlying condition with hyperosmolarity with coma

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E08.01 • 7 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Diabetes mellitus due to underlying condition with hyperosmolarity with coma Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Diabetes mellitus due to underlying condition with hyperosmolarity with coma?

Designated in federal medical registries as E08.01, Diabetes mellitus due to underlying condition with hyperosmolarity with coma falls under Diabetes & Glucose management, where peripheral monofilament testing [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

In Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01), physiological disruption stems from renal SGLT2 glucose in Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01: hyper-reabsorption), informing Type 1 & Type 2 Diabetes protocols that track Fasting Insulin [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] (3.0 – 7.0 uIU/mL (E08.01)).

Common Symptoms & Clinical Signs

  • • Presentation of Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01): tingling or numbness in Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01: in toes and)
  • • Secondary Diabetes mellitus due to underlying condition with hyperosmolarity with coma clinical sign: blurred vision fluctuations in Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01: or slower healing)
  • • Symptom flares in Diabetes mellitus due to underlying condition with hyperosmolarity with coma correlating with Fasting Plasma Glucose [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] deviation outside 75 – 95 mg/dL (E08.01)
  • • Functional diabetes & glucose impact requiring peripheral monofilament testing [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] evaluation (E08.01)

Diabetes mellitus due to underlying condition with hyperosmolarity with coma Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E08.01 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Type 1 & Type 2 Diabetes NLM Clinical Tables
Diagnostic / Lab Marker: Fasting Plasma Glucose [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] 75 – 95 mg/dL (E08.01) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Insulin [Diabetes mellitus due to underlying condition with hyperosmolarity with coma E08.01] 3.0 – 7.0 uIU/mL (E08.01) Clinical Reference Target Range
Diagnostic / Lab Marker: CGM Time-in-Range (70–140 in Diabetes mellitus due to underlying condition with hyperosmolarity with coma (E08.01: mg/dL)) > 85% (E08.01) Clinical Reference Target Range
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Treatment selection for Diabetes mellitus due to underlying condition with hyperosmolarity with coma depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Diabetes mellitus due to underlying condition with hyperosmolarity with coma)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of empagliflozin as add-on to metformin for type 2: What a 4,256-Participant Study Found

EMPA as add-on to MET was well tolerated and provided additional benefits beyond glucose lowering, such as weight loss and blood pressure reduction.

European journal of clinical pharmacology • 2016-06-15 • Meta-Analysis
N = 4,256 99/100 PMID 26832915 ↗
New Insights on Is metformin still the most efficacious first-line oral hypoglycaemic drug in: What a 33,830-Participant Study Found

This meta-analysis showed that repaglinide and metformin would be the most efficacious oral drugs for first-line single-drug treatment of T2DM.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2019-01-15 • Meta-Analysis
N = 33,830 99/100 PMID 30230172 ↗
New Insights on Heart and blood vessel outcomes of liraglutide in patients with type 2: What a 14,608-Participant Study Found

Our results suggest that liraglutide treatment decreases the risk of MACE, AMI, all-cause death and heart and blood vessel death among patients with type 2 diabetes.

Medicine • 2019-11-15 • Meta-Analysis
N = 14,608 99/100 PMID 31725627 ↗
New Insights on Urinary tract infections in patients with diabetes treated with: What a 3,152-Participant Study Found

Treatment of type 2 diabetes with once-daily dapagliflozin 5 or 10mg is accompanied by a slightly increased risk of urinary tract infection.

Journal of diabetes and its complications • 2013-01-15 • Meta-Analysis
N = 3,152 99/100 PMID 23849632 ↗
New Insights on Effect of metformin on microvascular outcomes in patients with type 2: What a 18,181-Participant Study Found

There is no evidence of clinically significant beneficial effect of metformin therapy as compared to other glucose-lowering medications or placebo on the examined microvascular complications.

Diabetes research and clinical practice • 2022-04-15 • Meta-Analysis
N = 18,181 99/100 PMID 35247521 ↗
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