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Cholesterol, Triglycerides & Lipids • ICD-10-CM E78.6

Lipoprotein deficiency

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E78.6 • 7 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Lipoprotein deficiency Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Lipoprotein deficiency?

Designated in federal medical registries as E78.6, Lipoprotein deficiency falls under Cholesterol & Lipids management, where fasting lipid fractionation [Lipoprotein deficiency E78.6] establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Lipoprotein deficiency (E78.6) features lipoprotein lipase insufficiency [Lipoprotein deficiency E78.6]. therapeutic stabilization in cholesterol & lipids is verified against Fasting Triglycerides [Lipoprotein deficiency E78.6].

Common Symptoms & Clinical Signs

  • • Presentation of Lipoprotein deficiency (E78.6): achilles tendon thickening, in Lipoprotein deficiency (E78.6: xanthelasma, or premature)
  • • Secondary Lipoprotein deficiency clinical sign: coronary artery calcium [Lipoprotein deficiency E78.6]
  • • Symptom flares in Lipoprotein deficiency correlating with LDL Cholesterol [Lipoprotein deficiency E78.6] deviation outside < 85 mg/dL (E78.6)
  • • Functional cholesterol & lipids impact requiring fasting lipid fractionation [Lipoprotein deficiency E78.6] evaluation (E78.6)

Lipoprotein deficiency Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E78.6 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cholesterol, Triglycerides & Lipids NLM Clinical Tables
Diagnostic / Lab Marker: LDL Cholesterol [Lipoprotein deficiency E78.6] < 85 mg/dL (E78.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Triglycerides [Lipoprotein deficiency E78.6] < 100 mg/dL (E78.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Lipoprotein(a) [Lp(a)] [Lipoprotein deficiency E78.6] < 75 nmol/L (E78.6) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Lipoprotein deficiency

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Pitavastatin Livalo • RxCUI 861643 HMG-CoA Reductase Inhibitor 81% $0.8365 $ 20.04 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Lipoprotein deficiency)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Factors Associated With Enhanced Low-Density Lipoprotein Cholesterol Lowering: What a 2,321-Participant Study Found

Factors including statin absence, female sex, diabetes history, ezetimibe use, and a higher high-sensitivity C-reactive protein level may be useful to identify patients who may have a greater LDL-C reduction with BA.

Journal of the American Heart Association • 2022-08-02 • Phase III Randomized Trial
N = 2,321 96/100 PMID 35916348 ↗
New Insights on Rosuvastatin versus atorvastatin on small dense low-density: What a 7,802-Participant Study Found

Rosuvastatin rather than atorvastatin therapy is likely more effective in reduction of sdLDL levels.

Heart and vessels • 2014-05-15 • Meta-Analysis
N = 7,802 94/100 PMID 23644555 ↗
New Insights on Elevated Lipoprotein(a) Predicts Recurrent heart attack in Diabetic Patients: What a 7,887-Participant Study Found

Elevated Lp(a) was associated with increased risk of recurrent MI in patients with diabetes after ACS or PCI.

Clinical cardiology • 2026-11-15 • Meta-Analysis
N = 7,887 94/100 PMID 42965402 ↗
New Insights on Safety of low lipoprotein(a) levels: the FOURIER: What a 564-Participant Study Found

In patients with ASCVD, low Lp(a) concentration was not associated with an increased risk of most adverse safety outcomes, but lower Lp(a) was associated with an increased risk of prevalent and incident DM.

European heart journal • 2026-10-26 • Phase III Randomized Trial
N = 564 93/100 PMID 42234492 ↗
Are post-treatment low-density lipoprotein subclass pattern analyses potentially misleading?

When assessing the effects of escalating cholesterol-lowering therapy, effects upon Pattern B alone to assess coronary heart disease risk may be misleading when interpreted without considerations of other lipid effects, such...

Lipids in health and disease • 2010-11-30 • Randomized Controlled Trial
N = 579 93/100 PMID 21118495 ↗
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