Chronic Kidney Disease & Electrolytes • ICD-10-CM E87.5
Potassium - high (hyperkalemia)
Also known as: Hyperkalemia
Audited by the DotMD AI Specialist Council
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FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E87.5 • 8 Linked .gov / PubMed Citations
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Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary
Potassium - high (hyperkalemia) Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Clinical triage of Potassium - high (hyperkalemia) (also termed Hyperkalemia) (E87.5) in Kidney & Renal relies on spot urine albumin-to-creatinine in Potassium - high (hyperkalemia) (E87.5: ratio), guiding step-wise therapeutic adjustments toward Serum Potassium, Bicarbonate in Potassium - high (hyperkalemia) (E87.5: & Phosphorus) (K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (E87.5)).
- 2 Real-world patient consensus: Clinical coding for Potassium - high (hyperkalemia) uses ICD-10 E87.5 across Kidney & Renal specialty care.
- 3 Typical cash cost range: Primary evaluation for Potassium - high (hyperkalemia) incorporates spot urine albumin-to-creatinine in Potassium - high (hyperkalemia) (E87.5: ratio) and symptom diary review.
- 4 Top reported side effects / signs: Longitudinal Potassium - high (hyperkalemia) monitoring tracks Urine Albumin-to-Creatinine Ratio in Potassium - high (hyperkalemia) (E87.5: (uACR)) toward < 15 mg/g (< 30 mg/g normal) (E87.5).
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What Is Potassium - high (hyperkalemia)?
Clinical triage of Potassium - high (hyperkalemia) (also termed Hyperkalemia) (E87.5) in Kidney & Renal relies on spot urine albumin-to-creatinine in Potassium - high (hyperkalemia) (E87.5: ratio), guiding step-wise therapeutic adjustments toward Serum Potassium, Bicarbonate in Potassium - high (hyperkalemia) (E87.5: & Phosphorus) (K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (E87.5)).
Pathophysiology, Underlying Causes & Clinical Presentation
Mechanistic hallmarks of Potassium - high (hyperkalemia) (E87.5) center on impaired nephron solute/acid-base in Potassium - high (hyperkalemia) (E87.5: clearance). targeted kidney & renal interventions aim to normalize Urine Albumin-to-Creatinine Ratio in Potassium - high (hyperkalemia) (E87.5: (uACR)).
Common Symptoms & Clinical Signs
- • Presentation of Potassium - high (hyperkalemia) (E87.5): changes in urine in Potassium - high (hyperkalemia) (E87.5: output volume, nocturnal)
- • Secondary Potassium - high (hyperkalemia) clinical sign: asymptomatic decline in in Potassium - high (hyperkalemia) (E87.5: eGFR or persistent)
- • Symptom flares in Potassium - high (hyperkalemia) correlating with Urine Albumin-to-Creatinine Ratio in Potassium - high (hyperkalemia) (E87.5: (uACR)) deviation outside < 15 mg/g (< 30 mg/g normal) (E87.5)
- • Functional kidney & renal impact requiring spot urine albumin-to-creatinine in Potassium - high (hyperkalemia) (E87.5: ratio) evaluation (E87.5)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Potassium - high (hyperkalemia) Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | E87.5 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Chronic Kidney Disease & Electrolytes | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio in Potassium - high (hyperkalemia) (E87.5: (uACR)) | < 15 mg/g (< 30 mg/g normal) (E87.5) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Serum Potassium, Bicarbonate in Potassium - high (hyperkalemia) (E87.5: & Phosphorus) | K+ 3.8–4.8 mEq/L; HCO3 23–29 mEq/L (E87.5) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: eGFR (Creatinine + in Potassium - high (hyperkalemia) (E87.5: Cystatin C)) | >= 90 mL/min/1.73m2 (E87.5) | Clinical Reference Target Range |
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance
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FDA-Monographed Medications & Public Cash Price Reference for Potassium - high (hyperkalemia)
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Potassium Phosphates (Potassium Phosphate, Monobasic Potassium Phosphate, Dibasic) Potassium Phosphates • RxCUI 1928569 | Osmotic Laxative | 79% | $2.3400 | $ 176.98 /mo |
| Potassium Iodide Iosat, Sski • RxCUI 312541 | FDA Prescription Therapeutic Agent | 93% | $0.5900 | $ 32.39 /mo |
| Pylera (Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride) Pylera • RxCUI 1294619-B61269381 | Nitroimidazole Antimicrobial | 75% | $2.4278 | $ 91.54 /mo |
| Augmentin Es-600 (Amoxicillin and Clavulanate Potassium) Augmentin Es-600 • RxCUI RXN-B81964003 | Penicillin-class Antibacterial | 87% | $0.0179 | $ 9.79 /mo |
| Urocit-K (Potassium Citrate) Urocit-K • RxCUI 199381-B01780615 | Anti-coagulant | 85% | $1.8600 | $ 7.21 /mo |
| Pokonza (Potassium Chloride) Pokonza • RxCUI 1867544-B15370306 | Osmotic Laxative | 83% | $27.4582 | $ 640.00 /mo |
| Potassium Phosphate Potassium Phosphate Generic • RxCUI RXN-70069746-3119 | Osmotic Laxative | 90% | $0.7500 | $ 38.88 /mo |
| Potassium Chloride and Dextrose Monohydrate Potassium Chloride in Dextrose • RxCUI RXN-03380683-3111 | Osmotic Laxative | 92% | $0.1900 | $ 16.20 /mo |
| Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride Pylera • RxCUI 1294619 | Nitroimidazole Antimicrobial | 81% | $2.4278 | $ 106.82 /mo |
| Veltassa (Patiromer) Veltassa • RxCUI 1716215 | Potassium Binder | 87% | $34.0169 | $ 640.00 /mo |
| Pfizerpen (Penicillin G Potassium) Pfizerpen • RxCUI 995906 | Penicillin-class Antibacterial | 74% | $0.0442 | $ 11.68 /mo |
| Penicillin V Potassium Beepen-VK • RxCUI 834061 | Penicillin-class Antibacterial | 76% | $0.0977 | $ 6.21 /mo |
| Penicillin G Potassium Pfizerpen • RxCUI 863538 | Penicillin-class Antibacterial | 77% | $0.0442 | $ 10.29 /mo |
| Effer-K 20 Meq Unflavored (Potassium Bicarbonate) Effer-K 20 Meq Unflavored • RxCUI 1111263 | Osmotic Laxative | 87% | $0.5196 | $ 45.91 /mo |
| Losortan Potassium (Losartan Potassium) Losortan Potassium • RxCUI 979480-B687888639 | Angiotensin 2 Receptor Blocker | 88% | $0.0208 | $ 9.99 /mo |
| Kali Phosphoricum (Potassium Phosphate, Dibasic) Kali Phosphoricum • RxCUI RXN-B02202908 | Over-the-Counter Clinical Monograph | 89% | $3.2100 | $ 239.62 /mo |
Dr. Lin (AI PubMed Clinical Trial Lead)
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Potassium - high (hyperkalemia))
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Fixed-dose Combinations of Amlodipine/Losartan Potassium/Chlorthalidone and: What a 328-Participant Study Found Of 330 patients from 33 medical centers, 328 patients who had available efficacy data were analyzed. Clinical therapeutics • 2017-10-15 • Phase III Randomized Trial | N = 328 | 93/100 | PMID 28939406 ↗ |
| New Insights on Magnesium and potassium supplementation on trouble sleeping and sleep hormones in: What a 320-Participant Study Found The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). Frontiers in endocrinology • 2024-01-15 • Randomized Controlled Trial | N = 320 | 93/100 | PMID 39534260 ↗ |
| Can This Approach Help? Inside the Latest Research on Phase III trial of sodium dichloroacetate for pyruvate dehydrogenase complex DCA decreased plasma lactate -0.48 (0.82) mmol/L (-20%; P = 0.006). JCI insight • 2026-09-22 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 42770298 ↗ |
| Can This Approach Help? Inside the Latest Research on Reduction in the magnitude of serum potassium elevation in combination therapy In Japanese patients with type 2 diabetes and albuminuria treated with esaxerenone, concomitant use of SGLT2 inhibitor reduced the magnitude of serum potassium elevation without any change of its blood-pressure-lowering and... Journal of diabetes investigation • 2022-07-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 35199478 ↗ |
| Can This Approach Help? Inside the Latest Research on Effect of Food on the how the body absorbs the medicine, how the medicine works This flexibility may enhance its clinical utility as an acid-suppressive therapy. Clinical and translational science • 2026-11-15 • Randomized Controlled Trial | Multi-cohort | 82/100 | PMID 42963322 ↗ |
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