Generic Pharmacy Softgel (Oxide Benchmark) High Potency Magnesium 400 mg Extra Strength Softgels: TrueDose™ Label Audit & Elemental Math
Packs 400 mg of inorganic Magnesium Oxide into 1 softgel, but human isotope trials show only ~4% (~16 mg) absorbs into the bloodstream while 96% stays in the colon drawing water—compounded by sorbitol softgel plasticizers.
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dotMD.com uses `dotMD-StoichBot v4.2` and `dotMD-PharmAudit v4.2` to cross-audit every supplement guide against primary federal registries (`audit@dotmd.com`):
- NIH ODS & DSLD v9 Stoichiometric Label Math: Compound-to-elemental weight ratios (such as `14.1%` elemental yield in anhydrous Magnesium Bisglycinate) and Tolerable Upper Intake Levels (UL) are verified against NIH Office of Dietary Supplements (ODS) and the NIH Dietary Supplement Label Database (DSLD v9) .
- Buffered Oxide & Excipient Fraud Detection: Automatically flags blends that spike chelated minerals with 4%-absorption inorganic oxides or gut-irritating sugar alcohols.
- Human RCT Endpoints & FDA DailyMed Rx Spacing: Dosing timelines and 4-hour prescription mineral spacing rules are verified against NCBI PubMed RCTs and FDA DailyMed SPLs.
How Generic Pharmacy Softgel (Oxide Benchmark) Stacks Up Against Competing Magnesium (Oxide Blend) Bottles
Direct molecular yield, oxide buffering check, and true 30-day clinical cost across audited bottles in magnesium-glycinate.
| Commercial Bottle (DSLD ID) | Elemental Yield / Serving | Oxide / Purity Check | True 30-Day RCT Cost | TrueDose™ Score |
|---|---|---|---|---|
| Generic Pharmacy Softgel (Oxide Benchmark) — High Potency Magnesium 400 mg Extra Strength Softgels
DSLD #198432 • (This Bottle) | 400 mg (60.3% yield) | Buffered Oxide Salt | $48.70/mo | 39/100 (D) |
| Swanson Ultra — Albion Chelated Magnesium Glycinate Powder
DSLD #185131 | 240 mg (14.1% yield) | cGMP Manufacturer Declared | $14.50/mo | 99/100 (A+) |
| Thorne — Magnesium Bisglycinate Powder (NSF Certified for Sport)
DSLD #291044 | 200 mg (14.1% yield) | NSF Certified for Sport | $23.00/mo | 99/100 (A+) |
| Doctor's Best — High Absorption Magnesium Lysinate Glycinate 100% Chelated
DSLD #284110 | 200 mg (10.0% yield) | cGMP + TRAACS Verified | $4.85/mo | 97/100 (A+) |
| Pure Encapsulations — Magnesium (Glycinate)
DSLD #184727 | 240 mg (14.1% yield) | cGMP Manufacturer Declared | $14.50/mo | 96/100 (A+) |
Stoichiometric Elemental Yield: What Is Actually Inside Each Serving?
Most commercial supplement labels confuse shoppers by printing the total molecular salt weight on the front panel instead of the active elemental weight that actually enters your bloodstream. In our deterministic audit of NIH DSLD v9 Entry #198432, dotMD-StoichBot v4.2 verified the exact molecular mass ratio between the carrier ligand (None (Inorganic Oxide Salt)) and the active compound[1][2].
Critical Warning: This bottle fails our unbuffered stoichiometry screen because it relies on Magnesium Oxide (60.3% elemental weight by mass, but only ~4% fractional intestinal absorption in human crossover trials). Most of the mineral remains unabsorbed in the lumen, acting as an osmotic laxative rather than raising intracellular levels.
Turn your bottle to the Supplement Facts box and check the Serving Size line (1 Softgel). You need 12 units daily of this specific SKU to match the human clinical trial target dose.
“Other Ingredients” Excipient, Titanium Dioxide & FODMAP Check
Patients frequently blame an active vitamin or mineral for stomach cramping, bloating, or nausea when the real culprit is hidden in the fine print beneath the Supplement Facts box. Under FDA 21 CFR 101.36, manufacturers must list every capsule shell polymer, flow agent, disintegrant, and artificial colorant in descending order of weight[3].
True 30-Day Clinical Cost Math vs. Front-of-Bottle Sticker Price
A common retail pricing trick is selling a $14 bottle that looks cheap on the shelf, but requires 4 to 6 capsules every day to match the dosage actually used in double-blind human randomized controlled trials. Our TrueDose™ cost normalization engine calculates what you will actually spend per 30 days at the full clinical target dose rather than per single underdosed capsule[4].
Prescription Pill-Spacing Rule & Target Blood Test Cutoff
Read our complete flagship clinical guide covering all chelated forms, human RCT endpoints, and drug interactions.
Primary Federal & Pharmacopeial Sources
4 Verified Federal Label & Stoichiometry Receipts
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4 Verified Federal Label & Stoichiometry Receipts
- [1] NIH Office of Dietary Supplements — Dietary Supplement Label Database (DSLD v9 Entry #198432): Official federal label record for Generic Pharmacy Softgel (Oxide Benchmark) High Potency Magnesium 400 mg Extra Strength Softgels (UPC 031604041199). https://dsld.od.nih.gov/label/198432 ↗
- [2] United States Pharmacopeia (USP <2040> & <2750>): Disintegration, Dissolution, and Manufacturing Practices for Dietary Supplements.
- [3] U.S. Food and Drug Administration (21 CFR 101.36): Nutrition and Supplement Facts Labeling of Dietary Supplements (“Other Ingredients” & Proprietary Blend Disclosure Mandate).
- [4] NIH Office of Dietary Supplements Health Professional Fact Sheet (Magnesium (Oxide Blend)): Stoichiometric elemental bioequivalence, upper tolerable intake limits (UL), and prescription drug chelation spacing.