Open Community Question @ThyroidMorning_CA • 45-59M • Testosterone cypionate 100 m • Week 16

▲ 22 Helpful • 2 Peer Replies

Male • Age 45-59 • Week 16 Protocol Check: lipid and hematocrit labs on testosterone cypionate plus atorvastatin and amlodipine?

Prompt for men combining testosterone cypionate (TRT) with a statin and a blood pressure drug such as amlodipine. We want to compare how people time labs and what they track. Please share: (1) your testosterone dose and injection schedule (for example 100 mg weekly vs 50 mg twice weekly), (2) whether you draw trough or mid-cycle, (3) LDL-C, ApoB, HDL and non-HDL before and after 12-16 weeks, (4) hematocrit and PSA trends, and (5) home blood pressure averages. Did your lipid numbers shift, particularly HDL? Did anyone need to change statin dose? Also tell us whether amlodipine caused ankle swelling, and whether you take oral minoxidil for hair loss, since it can cause fluid retention and a faster heart rate. Please do not post prescription sources or advice to skip monitoring.

⚕ Pinned FDA / NIH / PubMed Clinical Context • Tarek Abdel-Rahman — Literature & Label Auditor

The FDA labeling for testosterone products warns of blood pressure increases and polycythemia, and the TRAVERSE trial (NEJM 2023, n=5,246) found that testosterone was noninferior to placebo for major cardiac events but showed higher atrial fibrillation and acute kidney injury rates. Atorvastatin labeling lists no dose limit with amlodipine, unlike simvastatin, which is capped at 20 mg.

Connected Clinical Guides: Condition: Hyperlipidemia Condition: Hypertension Rx: Atorvastatin Rx: Rosuvastatin Supplement: CoQ10 (Ubiquinol) Supplement: Omega-3 EPA/DHA

Find Preventive Cardiologists (CPT 93306) →

Verified Peer Replies (2)

@RedRockClimber_NV • Age 45-59 • Week 24

On 80 mg twice weekly, my hematocrit rose from 46% to 51% by week 12 while ApoB stayed around 70 on atorvastatin 20 mg. I draw trough labs the morning before an injection so numbers compare cleanly each time.

@FingerLakesHiker_NY • Verified Cohort Member • Week 15

Useful to record the draw timing, since cypionate levels swing between injections. Many clinicians review hematocrit and escalate if it exceeds 52-54%. Home blood pressure should be taken seated after 5 minutes of rest, 2 readings each morning and evening, then averaged over 7 days before anyone adjusts amlodipine.