Long-term human survival cohorts and Phase 3 prevention trials covering UKPDS 34 / TAME Metformin AMPK longevity pathways, muscle protein synthesis across eight decades of life, and adult vaccine coadministration trials. Explore 817 indexed studies and multi-trial syntheses with verified PubMed PMIDs, participant sample sizes (N), and Absolute vs. Relative Risk numbers.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
These data demonstrate that sutimlimab has potential to be an important advancement in the treatment of CAD.
Liraglutide (n = 22) compared with placebo (n = 25) did not change Edec (+0.2 mL/s 2 × 10 -3 (-0.3;0.6)), E/A (-0.09 (-0.23;0.05)), E/Ea (+0.1 (-1.2;1.3)) and ejection fraction (0% (-3;2)), but decreased stroke volume (-9 mL...
Our findings suggest that using IL-6 inhibitors in severe COVID-19 patients with low S-spike antibody titers may improve clinical outcomes.
NCT00047385 © RSNA, 2026 Supplemental material is available for this article.
Multivariate regression analysis demonstrated that fluctuations in lipoprotein subfractions were not influenced by changes in BMI or HbA1c.
In terms of relapse-free survival, the superiority of preoperative denosumab was not observed in patients with giant cell tumor of bone without possible post-operative large bone defect.
GRF6019 demonstrated excellent safety, feasibility, and tolerability.
Sildenafil reduces SaO2 at rest while breathing air, this was not exacerbated by hypoxia, suggesting increased ventilation-perfusion mismatching due to lung vasodilation in poorly ventilated lung regions.
These results highlight that both spleen- and anemia-related benefits of momelotinib correlate with improved OS, supporting prioritization of TI in anemic patients for optimal long-term outcomes, and suggest that momelotinib...
The detection of postoperative ctDNA after secondary resection of CRLM is a promising prognostic factor for RFS and appeared to be highly correlated with pathologic response.
The study showed that women with IDA improved their postural performance regardless of the intervention used. However, an 8-week program of extremely low-volume HIIT combined with plyometric exercises and iron supplementation had a more beneficial effect compared to traditional iron therapy.
CT may be safely performed with a favorable prognosis in EC.
Intense aerobic exercise in patients with diabetes and prediabetes under metformin treatment reduces free-living 72-h blood hyperglycemic peaks.
Sleep, a modifiable behavior, may be a secondary prevention target to reduce the risk of recurrent event and death following stroke.
Our study identifies key immune contributors correlated with response to neoadjuvant therapies and a panel of TAAs in non-responders.
No important safety risks were identified, and TAK-003 was well tolerated irrespective of age, gender, or baseline dengue serostatus in recipients aged 4-60 years.
Primary series and booster vaccination of the DTaP-IPV-HB-PRP~T vaccine were immunogenic and safe in HIV-exposed infected and uninfected infants.
In CAD patients, the combination treatment with statins and exercise resulted in significant amelioration of arterial wall stiffness, at least in part, through reduction of circulating basophils.
The trial included 25 000 participants.
As add-on therapy to metformin and sulfonylurea, both dulaglutide and empagliflozin improved blood sugar control, with no significant between-group difference observed in this exploratory pilot study.
Continued clinical improvement during prolonged rilonacept treatment corresponded with improvement on CMR, including reduced pericardial thickness, resolution of pericardial oedema, and resolution of LGE.
Orally administered, once-daily berotralstat 150 mg significantly reduced the frequency of HAE attacks and was safe and well tolerated, supporting its use as a prophylactic therapy in patients with type 1 or 2 HAE in Japan.
A comprehensive program of oropharyngeal exercises produced better changes in fatigue severity and daytime sleepiness in moderate to severe OSA patients compared to the combination of aerobic and oropharyngeal exercises.
The Tumaini trial is hoping to find effective vaccines against Bundibugyo virus infection, which has killed more than 5000 people in DR Congo. Talha Burki reports.
Even as smoking prevalence among adults in many high-income countries has fallen, the global burden of mortality attributed to tobacco has been estimated at 1 billion lives for the 21st century. We remain in the midst of an entirely preventable pandemic.
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04655-5 A multimodal vision language foundation model, EVLF-FM, integrates extensive clinical data and advanced training techniques, achieving superior diagnostic accuracy and explainab
Few explicit policies exist to address cognitive decline among aging physicians, a study published in JAMA Health Forum found.
The US Centers for Disease Control and Prevention (CDC) issued a health advisory in response to reports of increased human exposure to rabid or possibly rabid animals.
In the absence of updated federal guidance for the 2026 to 2027 respiratory virus season, US medical societies have published their own vaccine recommendations based on evidence reviews from the Vaccine Integrity Project, an initiative of the Center for Infect
The treatment landscape of EGFR-mutated non-small-cell lung cancer harbouring exon 19 deletion or L858R mutations has advanced remarkably over the past two decades. Although acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) is inevitable in most pa
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
