Long-term human survival cohorts and Phase 3 prevention trials covering UKPDS 34 / TAME Metformin AMPK longevity pathways, muscle protein synthesis across eight decades of life, and adult vaccine coadministration trials. Explore 817 indexed studies and multi-trial syntheses with verified PubMed PMIDs, participant sample sizes (N), and Absolute vs. Relative Risk numbers.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
• Long-acting testosterone is effective in improving health-related quality of life as assessed by the AMS scale in men with TDS.
In the prescribed treatment plan, ONS-5010 exhibited strong effectiveness in improving or stabilizing visual acuity and was also well tolerated.
In this interim analysis, short-course radiotherapy followed by camrelizumab and CAPOX significantly improved 3-year event-free survival in.
Intraperitoneal local anaesthetic did not shorten the time to RIOT among women undergoing surgery for advanced ovarian cancer in this trial.
In this final analysis with up to 52 months of follow-up (median 45 months), ibrutinib plus obinutuzumab showed sustained clinical benefit, in terms of progression- free survival, in first-line treatment of chronic lymphocytic...
This study failed to demonstrate a survival advantage after eltrombopag addition, at variance with previous reports, but shows that initiating eltrombopag after chemotherapy washout is feasible and safe, and resulted in a decreased need for platelet transfusions.
The immunogenicity and safety profiles of CYD-TDV and quadrivalent HPV vaccines were unaffected when administered concomitantly or sequentially in dengue-seropositive children.
Overall survival, locoregional and distant recurrences was not significantly difference for patients undergoing either segmentectomy or lobectomy for stage Ia NSCLC.
Machine learning algorithms predicted outcomes and dosing frequency with high accuracy and may help inform patients' and clinicians' expectations during MEfCRVO management.
There were similar recurrence and survival outcomes but less morbidity from SH compared to RH in patients with and without very low-risk early-stage cervical cancer from the SHAPE trial.
In this article, for the first time, we externally validate the association of higher CTC counts with inferior survival outcomes in men with mCSPC and show a distinct associated tumor genomic landscape.
No participant had hydroxyurea therapy stopped for myelosuppression.
No serious side effects were reported.
SC rituximab improves PFS for patients with low-tumor burden FL when used in induction followed by short maintenance.
Sleep disturbance may be one of the clinical signs for severe hypogonadism.
In resistance-trained men, 16 weeks of high protein intake did not produce statistically detectable differences in renal biomarker or eGFR changes compared with moderate protein intake, irrespective of training modality.
We hypothesize that the multimodal program will demonstrate beneficial effects on adolescent psychological outcomes compared with usual practice.
Our findings indicate acceptable feasibility and reliability, with moderate convergent and predictive validity. This simple survey can serve as a useful tool for evaluating hard-to-reach areas and guiding resource allocation in public health interventions, including mass drug administration campaigns.
This randomized, experimental field trial comparing two currently used standard search procedures in the Norwegian SAR service showed that the RP Hoist Search was significantly more efficient than the Antenna Search for localizing buried avalanche victims, reducing total localization time by more than two minutes.
Resistance training combined with protein supplementation was not feasible during first-line chemotherapy in patients with incurable gastroesophageal cancer due to low accrual and low adherence to protein supplementation.
The protocol will provide preliminary evidence on the feasibility and initial evaluation of an intervention aimed at reducing electronic cigarette use, generating information to inform the design of future studies and prevention strategies for the Mexican university student population.
Plausibly, as in vivo VRC01 concentration waned, suppressed viruses-often evolving greater resistance because of selective pressure-emerged as detectable infections.
NEW & NOTEWORTHY This study investigates the impact of a home-based, video-monitored 12-wk exercise program, consisting of both endurance and resistance exercise, on skeletal muscle structural remodeling in persons with...
Supervised PSSE provided a statistically significant but clinically modest radiological benefit over self-directed exercise. This did not translate into a higher likelihood of clinically meaningful radiological improvement. No sustained clinically meaningful quality-of-life benefit was shown.
Clinicians should exercise caution when prescribing such combinations, particularly in high-risk patients. Further large-scale studies are needed to better quantify risk across different statins and antibiotic classes.
Supplemental material is available for this article. See also the editorial by Mesurolle and El Khoury in this issue.
Malignancy was associated with higher mortality among adults with sepsis or septic shock, with variation across mortality endpoints and clinical contexts. These findings support endpoint-specific prognostic assessment and highlight the need for future studies to incorporate more granular cancer characteristics.
This multimodal approach systematically identified precise NIBS targets, confirming established sites and revealing novel regions to broaden neuromodulation strategies for poststroke recovery.
Associations involving programme characteristics should be interpreted cautiously because they were derived from study-level meta-regression. Trial Registration: PROSPERO Registration CRD42024609379.
GMC ratio did not meet non‑inferiority: ratio 0.71 (95% CI 0.60-0.84; p : CTR2023189.
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
