Double-blind RCTs on Magnesium Bisglycinate NMDA/GABA receptor modulation and nocturnal cortisol reduction, antidepressant remission meta-analyses, SAMe augmentation trials, and optical smartwatch HRV validation studies. Explore 674 indexed studies and multi-trial syntheses with verified PubMed PMIDs, participant sample sizes (N), and Absolute vs. Relative Risk numbers.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
When considering the risk-benefit profile of antidepressants in the acute treatment of depression, these drugs do not seem to offer a clear advantage for children and adolescents.
Among adult patients with OSA, exercise as the sole intervention was associated with improved clinical outcomes.
Hypothyroidism is found to be associated with severity of OSA.
The results are consistent with our previously published findings in normotensive adults but further indicate that IMT can modulate blood pressure and plasma catecholamines in subjects with ongoing nighttime apnea and hypoxemia.
Although there was a significant reduction in AHI with OPT, the baseline AHI was not suppressed in majority of patients to the extent to call these patients as optimally treated.
Patients treated with oral appliances may experience deteriorations in disease severity and treatment efficacy during continuous long-term OA treatment.
The available data suggest that metformin exposure during the first trimester is not associated with major congenital malformations; that metformin reduces the risk of early pregnancy loss, preeclampsia, preterm delivery, and...
In addition, the random allocation of individuals to the two different combined treatment sequences (Arm A and Arm B) will allow us to understand the benefits of the sequential administration of CBT-I and PAP relative to...
The clinical implication of these results, the possible causal mechanisms of the cognitive impairments and the implication of these for future research were each discussed.
We discuss the rationale and design of ASCEND, the first large-scale randomized controlled trial evaluating efficacy of non-pharmacologic vs.
Intact activation in the frontoparietal network during response inhibition, a core cognitive function, predicts full symptom relief with antidepressant treatment, particularly for SSRIs, and may be a potential substrate of the...
This study suggests an association of cerebrovascular risk, but not executive function or processing speed, with treatment outcome of major depression with psychotic features in older adults.
Male non-responders to venlafaxine-XR had less activity originating from the left insular cortex.
Glossectomy significantly improves sleep outcomes as part of multilevel surgery in adult patients with OSA.
Low theta in frontal cortex and rACC are found in responders to antidepressant treatments with a small effect size.
The AASM and AADSM expect these guidelines to have a positive impact on professional behavior, patient outcomes, and, possibly, health care costs.
For payers, a home-based diagnostic pathway for obstructive sleep apnea with robust patient support incurs fewer costs than a laboratory-based pathway.
Fluid overload influences overnight rostral fluid shift and obstructive sleep apnea severity in patients with ESRD undergoing intermittent hemodialysis.
SR melatonin resulted in statistically significant decreases in sleep latency and WASO.
Current literature demonstrates that myofunctional therapy decreases apnea-hypopnea index by approximately 50% in adults and 62% in children.
The position device utilized in this study was effective in reducing supine sleep and AHI, which was significant in those with baseline AHI ≥20.
We have demonstrated for the first time that a second-generation antihistamine ameliorates nocturnal scratching behavior in eczema patients using a modified wristwatch-type acoustic scratching counting system that we have...
Trouble sleeping symptoms, while common in patients with chronic/recurrent MDD were not predictive of response, full symptom relief, or tolerability with either single or combined antidepressant medications.
Reduced suicidal ideation was best predicted by a combination of the independent improvements in both depression symptomatology and verbal memory.
Contrary to our original hypothesis, the ML phase was not associated with sympathoexcitation or exaggerated heart and blood vessel reactivity in sleep-deprived premenopausal women.
Improvement in immediate verbal memory exerted a direct influence on improvement in global function (p=0.006).
In this trial, sertraline treatment was associated with superior effectiveness in relation to depressive, cognitive, and behavioral symptoms.
Although we were not able to confirm effects of gonadal hormone treatment on 5-HT₁A receptor binding, our data do not preclude associations between sex steroid levels and serotonin, the neurotransmitter implicated most...
Patients with OSA appear to have increased high cholesterol (high total cholesterol, LDL, TG, and low HDL).
Primary analyses did not demonstrate that dual therapy outperformed both monotherapies in either timing of full symptom relief or full symptom relief rate.
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
