Double-blind RCTs on Magnesium Bisglycinate NMDA/GABA receptor modulation and nocturnal cortisol reduction, antidepressant remission meta-analyses, SAMe augmentation trials, and optical smartwatch HRV validation studies. Explore 674 indexed studies and multi-trial syntheses with verified PubMed PMIDs, participant sample sizes (N), and Absolute vs. Relative Risk numbers.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
COMISA is linked to sex-specific cognitive vulnerability, with older females showing worse verbal memory than males.
A more abnormal pattern of pretreatment VS dynamic response to reward expectancy (expected outcome value) and prediction error (difference between expected and actual outcome), likely reflecting serotonergic and dopaminergic...
Cognitive and psychiatric TEAEs were reported by similar numbers of cenobamate- and placebo-treated patients during gold-standard blind adjunctive cenobamate treatment (< 4 % of patients), and exposure-adjusted incidence rates...
ON-SXB significantly improved narcolepsy symptoms; its safety profile was consistent with SXB.
Ramelteon demonstrated a statistically significant reduction in LPS and a statistically significant increase in TST, with no apparent next-day residual effects, in patients with chronic primary trouble sleeping.
Women with a history of PMS and women with a high anxiety-related personality might respond with adverse mood effects to a combination of estrogen and sequential progestin and therefore a thorough evaluation should be made, at...
The combination treatments were as well tolerated as fluoxetine single-drug treatment and more clinically effective.
There was no significant difference in the outcomes between the SRS and WBRT in breast cancer patients with brain metastasis.
After an abrupt advance in sleep time, tasimelteon improved sleep initiation and maintenance concurrently with a shift in endogenous circadian rhythms.
Up to 52-weeks, daridorexant was well tolerated with sustained improvement in sleep onset, sleep maintenance and daytime functioning, supporting its long-term use in Japanese patients with trouble sleeping disorder.
The combination of escitalopram with BoNT/A is a significantly effective intervention in improving clinical efficacy and reducing the recurrence in patients with GAD and comorbid headache, and we believe that this approach...
The results demonstrate highly prevalent of medication overuse among individuals with CM.
LEM may be an important potential treatment option for patients with trouble sleeping in China.
When considering both treatment arms, a significant arousal group x time x treatment interaction emerged, highlighting specificity to the sertraline arm.
It is concluded that the Rhodiola capsule shows anti-depressive potency in patients with depression disorder when administered in dosages of either 0.3 or 0.6 g/day over a 12-week period.Rhodiola capsule can improve the...
Sleep disturbance may be one of the clinical signs for severe hypogonadism.
OnabotA was a cost-effective preventive treatment of chronic migraine versus topiramate. Although OnabotA had higher drug acquisition costs, these were offset by reduced HCRU costs due to fewer migraines, resulting in a low incremental cost per headache-day avoided versus topiramate.
MBI significantly improved the primary outcome of mindfulness (FFMQ) and showed promising exploratory improvements in processing speed (P300 latency) and sustained attention (CPT-IP). FER change may represent a potential indirect pathway associated with change in SQLS.
The available evidence suggests that the combination of Tai Chi and rTMS may improve overall sleep severity; however, this finding should be interpreted cautiously given the small number of trials and sensitivity to individual studies. Evidence for specific sleep parameters and emotional outcomes remains inconclusive.
The protocol will provide preliminary evidence on the feasibility and initial evaluation of an intervention aimed at reducing electronic cigarette use, generating information to inform the design of future studies and prevention strategies for the Mexican university student population.
Higher-intensity tACS plus DCT was feasible and well tolerated in older adults with MCI. Exploratory findings suggest that active stimulation may improve inhibitory control and facilitate transfer to selected cognitive domains. Confirmation in the ongoing randomized controlled trial is warranted.
In this randomised survey experiment, approval ratings were highly similar across psychiatric staff attire. Given this apparent parity, and the advantages in terms of hygiene and correct identification of staff, we believe that more consistent use of uniforms should be considered.
Because of the limited sample size, conclusions are primarily descriptive. Medicare-defined PAP adherence did not differ significantly between RPM and SOC.
CommonGround was considered an acceptable and appropriate space to access peer support, with the potential to positively impact psychological well-being by fostering shared understanding, support, and knowledge exchange.
Among 2366 US study patients, 2165 (91.5%) participated in cognitive assessments, 1078 in the CAS trial (529 CAS + IMM; 549 IMM alone) and 1087 in the CEA trial (543 CEA + IMM; 544 IMM alone); mean age was 70.1 years (SD, 7.7)...
A brief educational video effectively improved back pain beliefs but did not alter lifting behaviour or spinal motion.
These findings provide insight into the role of core beliefs about the self in the treatment of GAD.
The initiation of antipsychotic therapy is a critical clinical window for early intervention to mitigate the long-term metabolic and psychiatric consequences of antipsychotic-induced weight gain.
This review provides preliminary evidence that TCFMs may confer benefits on mental health and glycaemic regulation in patients with T2DM and comorbid depression. However, given the low certainty of the evidence, high heterogeneity, and methodological limitations, these findings should be interpreted cautiously.
Food intake delayed the time to reach C max (T max ) for both elunetirom and LL-340001. Elunetirom, administered orally as a liquid and as a solid formulation, was safe and well tolerated under fed and fasted conditions.
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
