Human isotope fractional absorption studies comparing chelated Magnesium Glycinate vs. Citrate vs. 4% Oxide, CYP2R1/CYP27B1 magnesium-dependent Vitamin D3 activation trials, and Metformin-induced Vitamin B12 holotranscobalamin depletion. Explore 4,327 indexed studies and multi-trial syntheses with verified PubMed PMIDs, participant sample sizes (N), and Absolute vs. Relative Risk numbers.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
A pragmatic, adaptive, randomized, multicenter phase II/III study evaluating vilobelimab for the treatment of severe COVID-19 found that patients receiving invasive mechanical ventilation.
These thresholds may be useful to aid the interpretation of Alzheimer's disease clinical trial data by illustrating meaningful within-patient progression over the course of a clinical trial via supplementary progressor...
We suggest that both APOE and TOMM40 genotypes may independently contribute to cognitive heterogeneity in the pre-MCI stages of AD.
The overall cost of Tanzania's HPV vaccination program was lower per.
The data demonstrate consistent and robust immunogenicity and safety results with a freeze-dried formulation of MVA-BN.
Sulopenem was noninferior to ciprofloxacin in the treatment of uUTIs.
Sulopenem followed by oral sulopenem-etzadroxil/probenecid was not noninferior to ertapenem followed by oral step-down therapy for the treatment of cUTIs, driven by a lower rate of asymptomatic bacteriuria in those who...
HA-PCI reduces hippocampal atrophy at 4 and 12 months compared to regular PCI.
Physicist-patient consults improved the patient experience by decreasing anxiety and increasing satisfaction.
Etanercept single-drug treatment showed benefit over methotrexate in maintaining PRO scores.
OPac + E increased the confirmed tumor response versus IVpac, with trends in PFS and OS.
Totally, 21 subjects reported SAEs and all but one were considered irrelevant or probably irrelevant to vaccination.
No significant adverse effects were observed.
There was high concordance in HIV-1 drug resistance mutations in the CSF and plasma, suggesting intercompartmental mixing and possibly a lack of compartmentalization.
The zoliflodacin target GyrB was highly conserved among 27 151 global gonococcal isolates cultured in 1928-2021.
ClinicalTrials.gov NCT04019548, study protocol version 2.0_08/08/2019.
External-beam PBI for patients with low-risk breast cancer was noninferior to WBI in terms of breast induration.
After a 10-year follow-up, too, the MAD has been proven to be a successful treatment option.
Only 1% of events were infusion-related reactions.
Regrowth was higher in latanoprost and betamethasone-latanoprost groups than minoxidil.
Treated breast volume - not the breast size itself - is the risk factor for induration.
Oral TU offers a safe and effective long-term treatment option for men with hypogonadism.
Microneedling combined with minoxidil had better efficacy for female pattern hair loss during the treatment period and follow-up.
The combination of pollen extract with hyaluronic acid and vitamins is more effective than ibuprofen in improving symptoms and Quality of Life in patients affected with CP/CPPS and has less side effects.
Rosacea is likely to be underdiagnosed and undertreated in Japan because of the current lack of consensus guidelines and standardized therapy.
The unique mutation F486V in the BA.4/5 spike contributes to the increased evasion of antibody neutralization by sublineage BA.4/5.
The JIPANG study failed to show the superiority of pemetrexed plus cisplatin in terms of recurrence-free survival, as primary endpoint.
Direct inhibition of IL-6 with OKZ resulted in significant improvements in the signs and symptoms of autoimmune joint pain (autoimmune joint pain (rheumatoid arthritis)) compared with PBO in TNF-IR patients with a similar...
Real-world benefits and safety findings in the China SOLO2 cohort support the use of olaparib (300 mg twice daily) as maintenance treatment for Chinese patients with platinum-sensitive relapsed ovarian cancer and a BRCA mutation.
The identification of IL-6 production in vascular endothelia cells after alloimmune activation reveals another potential pathway for vasculitis as endothelia cell IL-6 may stimulate immune cell responses that are potentially...
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
