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★ Breakthrough Medical Research • 15 Landmark Multi-Trial Guides • 6,280 Indexed Studies

Randomized Controlled Human Trials (RCTs) (1,760 Indexed Studies)

Prospective randomized human trials, crossover pharmacokinetic studies, and ClinicalTrials.gov interventional readouts with direct participant sample sizes (N). Every study summary reports the trial design, participant sample size (N), primary outcome highlight, and direct link to the formal NCBI PubMed or federal record.

★ #1 Lead Breakthrough Study • NEJM SURMOUNT-1 (176 Weeks) N = 1,032 Adults • p < 0.001

Once-Weekly Tirzepatide Cuts Type 2 Diabetes Progression by 94% Over 3 Years—With a 22.9% Sustained Weight Reduction

The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).

Read the Full Breakthrough Breakdown → Jump to All 15 Landmark Breakthroughs ↓
Two biomedical scientists in white lab coats inside a sunlit medical research laboratory pipetting clinical assay samples and reviewing trial results
Inside the Clinical Evidence Lab: Our research desk audits 6,280 human trials from NEJM, The Lancet, JAMA, and NCBI PubMed—reporting true Absolute Risk Reduction (ARR) and sample sizes (N) without pharma spin.
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3. All Indexed Clinical Studies (1,760)

Randomized Controlled Human Trials (RCTs) (1,760)

Page 10 of 59 • Sorted by Participant Sample Size (N)
Randomized Controlled Trial PMID 42989979

Randomized Controlled Trial: Cost-effectiveness of onabotulinumtoxinA versus topiramate in chronic migraine in the US: an economic analysis of the FORWARD randomized trial

OnabotA was a cost-effective preventive treatment of chronic migraine versus topiramate. Although OnabotA had higher drug acquisition costs, these were offset by reduced HCRU costs due to fewer migraines, resulting in a low incremental cost per headache-day avoided versus topiramate.

Journal of medical economics • 2026-12-15 Read Study
Randomized Controlled Trial PMID 42990011

Randomized Controlled Trial: Mindfulness-Based Intervention Improves Cognitive Function in Patients With Schizophrenia in Remitted

MBI significantly improved the primary outcome of mindfulness (FFMQ) and showed promising exploratory improvements in processing speed (P300 latency) and sustained attention (CPT-IP). FER change may represent a potential indirect pathway associated with change in SQLS.

International journal of methods in psychiatric research • 2026-12-15 Read Study
Randomized Controlled Trial PMID 42990082

Randomized Controlled Trial: Development and evaluation of a subjective measurement of geographical hardness-to-reach: a survey of data collectors in a large-scale cluster randomised trial of azithromycin mass drug administration

Our findings indicate acceptable feasibility and reliability, with moderate convergent and predictive validity. This simple survey can serve as a useful tool for evaluating hard-to-reach areas and guiding resource allocation in public health interventions, including mass drug administration campaigns.

Journal of global health • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42993881

Randomized Controlled Trial: Oral Acarbose Inhibits Baseline Salivary Amylase and Blunts Early Postprandial Glycemia: Randomized Cross-Over Study

ΔBG at 30 min was significantly lower in T3 and T4 than in T2 (both P <.05) without trial order effect, while BG areas under the curve did not differ between T2 and T3. Inhibition of SAA by oral acarbose reduced the early postprandial increase in BG compared with intact SAA activity in healthy individuals.

JMIR formative research • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42993341

Randomized Controlled Trial: Testing the EQ-HWB-9 with seven-day versus today recall periods in dementia: variability and recall adherence under health fluctuations

No single recall period appears optimal for all PlwD. Recall period selection should consider individual health fluctuation patterns to improve the performance of HRQoL assessments in dementia.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42993298

Randomized Controlled Trial: Anti-plaque effect of a surface pre-reacted glass-ionomer-based prophylactic paste under cariogenic challenge

Under the conditions of this short-term in situ study, the tested S-PRG-based prophylactic paste (Pro-Care Gel) resulted in lower stainable plaque accumulation than the tested conventional paste (Herjos) and pumice/water. These findings are specific to the products and outcomes evaluated.

Clinical oral investigations • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42990085

Randomized Controlled Trial: Effects of a parenting and unconditional cash transfer intervention on child development and maternal well-being in urban Bangladesh: medium-term follow-up of a cluster randomised controlled trial

Although we found no benefit for the primary outcome of child IQ, a combined parenting and cash transfer intervention showed medium-term benefits compared to cash transfer alone for children's reading skills, home stimulation, mothers' childcare knowledge, depressive symptoms, and empowerment.

Journal of global health • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42992423

Randomized Controlled Trial: Effect of a dietary behaviour change education intervention on iron status and linear growth in children aged 6 to 59 months: a cluster-randomised controlled trial in rural Ethiopia

Community-based DIBE improved linear growth and coincided with reductions in IDA and stunting. Integrating practical nutrition education into routine child health services may improve nutritional outcomes in resource-limited settings.Trial registration: ClinicalTrials.gov:NCT04846062.Registered: 15 April 2021, View at: https://clinicaltri.

Primary health care research & development • 2026-11-06 Read Study
Randomized Controlled Trial PMID 42986046

Randomized Controlled Trial: [The design process and protocol for a cognitive-behavioral intervention to reduce electronic cigarette use among university students]

The protocol will provide preliminary evidence on the feasibility and initial evaluation of an intervention aimed at reducing electronic cigarette use, generating information to inform the design of future studies and prevention strategies for the Mexican university student population.

Revista espanola de salud publica • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42970454

Randomized Controlled Trial: An Exploratory Study of Image-Guided Cochlear Implant Intervention on Articulation and Phonological Processing in Children With Speech Sound Disorders

Articulation deficits, but not phonological processing deficits, improved over time among children with CIs. Future studies should assess the impact of IGCIP on articulation within a larger sample of CI users with articulation deficits to clarify its role in such improvements.

American journal of speech-language pathology • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42982936

Randomized Controlled Trial: Resistance training and protein supplementation in patients with incurable gastroesophageal cancer

Resistance training combined with protein supplementation was not feasible during first-line chemotherapy in patients with incurable gastroesophageal cancer due to low accrual and low adherence to protein supplementation.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42984166

Randomized Controlled Trial: Efficiency of Rescue Paramedic Hoist versus Underslung Antenna in Helicopter-Based Avalanche Searches

This randomized, experimental field trial comparing two currently used standard search procedures in the Norwegian SAR service showed that the RP Hoist Search was significantly more efficient than the Antenna Search for localizing buried avalanche victims, reducing total localization time by more than two minutes.

Prehospital and disaster medicine • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42986480

Randomized Controlled Trial: Feasibility and tolerability of combining 6 Hz transcranial alternating current stimulation (tACS) at 3.2 mA and digital cognitive training in older adults with mild cognitive impairment

Higher-intensity tACS plus DCT was feasible and well tolerated in older adults with MCI. Exploratory findings suggest that active stimulation may improve inhibitory control and facilitate transfer to selected cognitive domains. Confirmation in the ongoing randomized controlled trial is warranted.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42992688

Randomized Controlled Trial: Video-Based Micro-Teaching Protocol for Value Integration in Chinese Pre-Service Teacher Education

The combined value-focused instructional package improved immediate teaching-performance scores within the assessed micro-teaching setting. These findings concern task-specific instructional enactment rather than enduring changes in personal values or professional ethics.

Journal of visualized experiments : JoVE • 2026-11-05 Read Study
Randomized Controlled Trial PMID 42981179

Randomized Controlled Trial: Cannabidiol and fronto-parietal EEG connectivity in autistic children

This study provides preliminary evidence that 12 weeks of cannabidiol is associated with an increase in right fronto-parietal (F4-P8) functional connectivity in autistic children, most pronounced in the beta-band. Replication in larger samples is needed to confirm generalizability and clinical relevance.

Cerebral cortex (New York, N.Y. : 1991) • 2026-11-04 Read Study
Randomized Controlled Trial PMID 42983382

Randomized Controlled Trial: Influence of acellular dermal matrix on peri-implant soft tissue phenotype and marginal bone loss following immediate implant placement in the anterior maxilla

ADM was associated with improved peri-implant soft tissue phenotype and reduced marginal bone loss compared with d-PTFE membranes while maintaining comparable peri-implant health. These findings support the potential use of ADM during immediate implant placement in the anterior maxilla.

BMC oral health • 2026-11-04 Read Study
Randomized Controlled Trial PMID 42976283

Randomized Controlled Trial: Improving CommonGround, an Online Peer Support Intervention for People Living With Long-Term Physical Health Conditions and Subthreshold Depression: Theory of Change-Informed Qualitative Study

CommonGround was considered an acceptable and appropriate space to access peer support, with the potential to positively impact psychological well-being by fostering shared understanding, support, and knowledge exchange.

Journal of medical Internet research • 2026-11-03 Read Study
Randomized Controlled Trial PMID 42980319

Randomized Controlled Trial: Transbronchial Cryobiopsy for the Diagnosis of Peripheral Pulmonary Lesions: A Prospective Randomized Controlled Study

One patient in the TBCB group developed pneumothorax and recovered with conservative treatment. These findings show that R-EBUS-GS-assisted 1.1-mm ultrathin cryobiopsy is technically feasible for PPL sampling and provides larger, better-preserved histologic specimens, while improvement in pathological diagnostic yield was not statisticall.

Journal of visualized experiments : JoVE • 2026-11-03 Read Study
Evidence Methodology, PubMed Verification & YMYL Standards

Frequently Asked Questions About dotMD Clinical Trial Breakdowns

Why does dotMD report both Absolute Risk Reduction (ARR) and Relative Risk Reduction (RRR) on clinical trials?

Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.

How does dotMD separate human randomized controlled trials (RCTs) from animal or observational studies?

Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.

Why did dotMD replace synthetic "Study Rigor Scores" with primary PubMed PMIDs and trial metadata?

Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.

How do dotMD Research Breakdowns connect to Conditions, Medications, Supplements, and Specialist Doctors?

Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.