Prospective randomized human trials, crossover pharmacokinetic studies, and ClinicalTrials.gov interventional readouts with direct participant sample sizes (N). Every study summary reports the trial design, participant sample size (N), primary outcome highlight, and direct link to the formal NCBI PubMed or federal record.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
The adapted online model was feasible and acceptable, with preliminary improvements in physical quality of life, movement skills, and BMI metrics. Larger adequately powered trials are needed to confirm effectiveness and longer-term outcomes.
Supplemental material is available for this article. See also the editorial by Mesurolle and El Khoury in this issue.
Active warming was associated with lower cortisol levels, reduced analgesic use, and faster recovery. In total, active warming improved maternal recovery and neonatal adaptation, and its routine use as a simple, safe, and effective strategy to enhance perioperative outcomes may be warranted.
Both HIFEM and PFMT with biofeedback appear to be safe, acceptable, and effective non-surgical treatment options for women with POP. Although no significant differences were observed between the two interventions, these findings should be interpreted with caution because of the small sample size.
Food intake delayed the time to reach C max (T max ) for both elunetirom and LL-340001. Elunetirom, administered orally as a liquid and as a solid formulation, was safe and well tolerated under fed and fasted conditions.
Chronotherapeutic environmental interventions were feasible and safe in ICU care. Feasibility results highlighted challenges related to ICU logistics, sedation-related assessment limitations and pandemic-related disruptions. The unexpectedly low delirium incidence limited conclusions regarding intervention efficacy.
The Tomazoni measurement method was associated with substantially higher rates of central PICC tip positioning and reduced need for catheter withdrawal compared with the traditional method.
A brief psychoeducational intervention significantly reduced psychological stress in dermatology outpatients.
In individuals with remitted psychotic depression, continuation treatment with sertraline plus olanzapine was associated with better outcomes in HRQOL domains directly relevant to mental health than treatment with sertraline...
Sublingual minoxidil was an effective and well tolerated option in this population for promoting hair growth in trans people receiving testosterone.
Short-term treatment with daridorexant does not impair sleep-disordered breathing and may improve sleep in patients with severe OSA.
Delayed gastric emptying appears to play little direct role in appetite suppression induced by liraglutide.
Our findings support the use of dihydropyridine calcium channel blockers as a preferred alternative to β-blockers for the management of high blood pressure in HFpEF.
Mediation analysis supports a bile-acid-mediated suppression of inflammatory pathways linking microbial changes to antidepressant effects.
In this study, fluoxetine combined with CBT showed no significant advantage over fluoxetine single-drug treatment.
We found that pre-treatment frontopolar beta duration was significantly correlated with depression score change, with greater degree of symptom response linked to shorter beta events at baseline.
Findings suggest that PATH significantly reduces anxiety and depressive symptoms, particularly with continued use.
Oral quadruple therapy achieved greater glycaemic and metabolic improvement without compromising safety, compared with metformin uptitration, supporting its role as an intensification strategy.
Very high-intensity and high-intensity statin regimens differed minimally in achieving LDL-C targets, but very high-intensity regimens had higher rates of intolerance-related dose reduction.
In patients with T2D at intermediate risk for HFpEF, dapagliflozin was associated with more favorable changes in left ventricular diastolic function parameters compared with glibenclamide, accompanied by improvements in...
Ezetimibe added to high-intensity statin therapy was well tolerated and resulted in an immediate and robust additional decrease in circulating LDL-C concentrations, with a markedly higher proportion of participants achieving...
Notably, the incidence of adverse effects did not differ significantly among the three groups.
Bedtime telmisartan dosage improves nocturnal BP control, but morning dosage more successfully lowers exercise-induced BP spikes.
While both regimens alleviated subjective symptoms, significant pressure × time interactions were observed for RFD and lateral gastrocnemius logarithmic decrement, suggesting that compression pressure may influence the acute neuromuscular and mechanical responses to ICC.
URL: https://clinicaltrials.gov/study/NCT07529665. Date of registration: 2026-04-14.
This pilot study aims to evaluate the clinical efficacy of audio-proprio-phonatory training in patients with chronic subjective tinnitus and to objectively measure its effects using HD-EEG.
Pain and anxiety outcomes following cryotherapy did not differ significantly from those of the topical anesthetic agents, while treatment compliance was higher, suggesting that cryotherapy may be a promising non-pharmacological option, pending confirmation in non-inferiority trials. ClinicalTrials.gov NCT07198022.
Findings suggest that adolescents largely turn to peers and adults for information and guidance regarding condoms. In turn, the views and beliefs of others can influence attitudes towards condom use.
Propofol-fentanyl provides faster induction and LMA insertion, whereas sevoflurane offers superior blood flow and heart rate stability with comparable safety profiles in children patients.
This research is expected to provide "time-specific" evidence for exercise prescription to maximize the neurocognitive benefits and mitigate dementia risk in this population. Chinese Clinical Trial Registry: [http://www.chictr.org.cn], identifier [ChiCTR2300073737].
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
