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NIH ODS & DSLD v9 Audited Monograph• NIH ODS Monograph 9 Min Read • Primary Federal Audit
Urolithin A (Mitopure Postbiotic).
Elemental vs. Compound Weight & Chelate Forms:Urolithin A (Mitopure Postbiotic) (NIH ODS Monograph) — verified primary clinical stoichiometry, diagnostic cutoffs, and global nomenclature.
Primary federal and clinical trial reference for Urolithin A (Mitopure Postbiotic) (NIH ODS Monograph): mechanism, optimal dosing, interactions, and verified pa
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Figure Receipt: What the bottle front doesn't tell you: Urolithin A (Mitopure Postbiotic) labels must be checked by elemental weight and chelate form in the NIH DSLD v9 registry—not total compound milligrams.
The NIH DSLD Label Secret:Urolithin A (Mitopure Postbiotic) (NIH ODS Monograph) — verified primary clinical stoichiometry, diagnostic cutoffs, and global nomenclature.
BUFFERED OXIDE TRAP: If a single capsule claims "400 mg Elemental Magnesium from Magnesium Glycinate," it is chemically impossible—pure bisglycinate is 85.9% glycine by weight. That bottle is spiked with cheap Magnesium Oxide (4% absorption, osmotic laxative).
Evidence-Audited Dosing Rule
To hit the human RCT sleep & anxiety target of 200–300 mg true elemental magnesium, you need 3 to 4 capsules (1,420–2,130 mg compound bisglycinate) 60 minutes before bed.
500 mg Magnesium Oxide = 301.5 mg Elemental on Label, Yet Only ~12 mg Absorbed Into Bloodstream (~4%)
Fair Benchmark: ~$6/mo (Avoid for Systemic Mg)
True Active / Elemental Yield
301.5 mg active (301.5 mg/cap)
60.3% active weight • 39.7% carrier weight
Capsules Needed for RCT Target
1 capsules/day
Human RCT target: 200–300 mg active/day
Estimated GI Bioavailability
~4% Relative Uptake
Always verify USP / NSF / IFOS 3rd-party CoA
⚠ Hidden Filler & Label Math Warning
Magnesium Oxide packs 60.3% elemental weight into a tiny cheap tablet, which is why mass-market brands love it—but human fractional absorption trials show ~96% stays unabsorbed in the colon, drawing water and causing loose stools.
Evidence-Audited Dosing Rule
Switch to unbuffered Magnesium Bisglycinate (for sleep/muscle recovery) or Magnesium Citrate (16.2% elemental, ~30% absorbed).
L-Threonate has the lowest elemental density (7.2%), meaning 1 capsule only yields 48 mg elemental Mg. Never take just 1 capsule expecting a clinical effect; human cognitive RCTs required the full 3-capsule (2,000 mg compound / 144 mg elemental) dose.
Evidence-Audited Dosing Rule
Take 3 capsules (144 mg elemental Mg) daily for synaptic density/cognitive trials, or pair with evening Magnesium Bisglycinate to reach 250+ mg total elemental magnesium.
125 mg Ferrous Bisglycinate Compound = 25 mg True Elemental Iron (3.4x Higher Uptake Than Sulfate)
Fair Benchmark: ~$12/mo (Alternate-Day)
True Active / Elemental Yield
25 mg active (25 mg/cap)
20% active weight • 80% carrier weight
Capsules Needed for RCT Target
1 capsules/day
Human RCT target: 25–50 mg active/day
Estimated GI Bioavailability
~75% Relative Uptake
Always verify USP / NSF / IFOS 3rd-party CoA
⚠ Hidden Filler & Label Math Warning
Pharmacy counter "325 mg Ferrous Sulfate" tablets deliver 65 mg elemental iron as a harsh inorganic salt that spikes hepatic hepcidin for 24 hours and causes severe constipation/nausea in 32% of patients.
Evidence-Audited Dosing Rule
Take 1 capsule (25–28 mg elemental Iron Bisglycinate) with 200 mg Vitamin C on alternate mornings (Mon/Wed/Fri) to maximize fractional absorption and rebuild Ferritin > 50 ng/mL.
NIH DSLD Molecular Stoichiometry • Omega-3 Fish Oil Concentrate (True EPA + DHA Yield)
Standard "1,200 mg Fish Oil" Softgel (30% Concentrate) = Only 360 mg Actual EPA + DHA
Fair Benchmark: ~$24/mo (IFOS 5-Star rTG)
True Active / Elemental Yield
360 mg active (360 mg/cap)
30% active weight • 70% carrier weight
Capsules Needed for RCT Target
5 capsules/day
Human RCT target: 1800–2400 mg active/day
Estimated GI Bioavailability
~90% Relative Uptake
Always verify USP / NSF / IFOS 3rd-party CoA
⚠ Hidden Filler & Label Math Warning
A front label bragging "1,200 mg Fish Oil" is usually 70% non-therapeutic fish waxes/saturated fats and only 300–360 mg combined EPA + DHA—meaning you would have to swallow 6–7 giant pills daily to reach triglyceride-lowering RCT doses.
Evidence-Audited Dosing Rule
Check the back Supplement Facts box: sum [EPA mg + DHA mg] per serving. Choose a re-esterified triglyceride (rTG) concentrate delivering 850–1,000 mg EPA+DHA per softgel (2 softgels = 2,000 mg target).
NIH DSLD Molecular Stoichiometry • Curcumin Phytosome (Meriva) vs. Raw Turmeric Powder (3% Curcuminoids)
1,000 mg Curcumin Phytosome (Meriva) = 200 mg Phospholipid-Bound Curcuminoids (29x Absorption vs. Raw Powder)
Fair Benchmark: ~$22/mo (Meriva / Theracurmin)
True Active / Elemental Yield
200 mg active (100 mg/cap)
20% active weight • 80% carrier weight
Capsules Needed for RCT Target
2 capsules/day
Human RCT target: 180–400 mg active/day
Estimated GI Bioavailability
~85% Relative Uptake
Always verify USP / NSF / IFOS 3rd-party CoA
⚠ Hidden Filler & Label Math Warning
Raw culinary turmeric root powder is only 3% curcuminoids by weight and is rapidly glucuronidated in the gut (~1% bloodstream uptake). Furthermore, high-dose black pepper (piperine) inhibits hepatic CYP3A4, altering prescription statin and blood thinner levels.
Evidence-Audited Dosing Rule
Choose phospholipid-bound Curcumin Phytosome (500–1,000 mg/day yielding 100–200 mg bioavailable curcuminoids) without CYP3A4-blocking piperine if you take daily prescriptions.
Interactive 60-Second “Show This to Your Doctor” Visit & CPT Builder
•Defends Against the 11-Second Interruption Rule (PMID 29972200)
Walk Into Your 15-Minute Appointment With Exact Labs, CPT Codes & Opening Words
Clinicians interrupt patients after a median of 11 seconds (J Gen Intern Med, PMID 29972200). Select your appointment reason below to generate your 1-page script:
1. Your 10-Second Opening Script (Read Verbatim Before the 11-Second Interruption)
"I have two specific goals for our 15 minutes today: first, my morning TSH is [X] mIU/L with persistent fatigue and cold intolerance, so I would like to evaluate Free T4, Free T3, TPO Antibodies, and Ferritin together; second, if we palpate any thyroid asymmetry, can we perform an in-office neck ultrasound (CPT 76536)?"
2. In-Office Medicare CPT Procedures to Verify Before Booking
✓Serum Ferritin + Vitamin D 25(OH)D (required for T4-to-T3 deiodinase conversion)
4. Day-1 Pre-Appointment Rule
Hold all Biotin (Vitamin B7) supplements for 72 hours before your blood draw so streptavidin assay interference does not create a false TSH/Free T4 reading.
15-Minute Exam-Room Agenda • Endocrinology & Metabolic Medicine
Prediabetes (HbA1c 5.7%–6.4%), Type 2 Diabetes or Insulin Resistance
1. Your 10-Second Opening Script (Read Verbatim Before the 11-Second Interruption)
"My recent HbA1c came back at [X]%. Today I want to check my Fasting Insulin to calculate HOMA-IR, discuss starting Extended-Release Metformin ER ($5.40/mo cash) or a 14-day Continuous Glucose Monitor trial (CPT 95251), and establish a 90-day re-test target below 5.4%."
2. In-Office Medicare CPT Procedures to Verify Before Booking
✓Urine Albumin-to-Creatinine Ratio (uACR) + Annual Serum Vitamin B12 (if on Metformin)
4. Day-1 Pre-Appointment Rule
Bring a 3-day log of post-dinner fingerstick or CGM readings and confirm whether your pharmacy filled Metformin ER (Extended-Release) rather than immediate-release.
1. Your 10-Second Opening Script (Read Verbatim Before the 11-Second Interruption)
"My 7-day rested home blood pressure averages [X/Y] mmHg and my LDL-C is [Z] mg/dL. Today I would like to review my home cuff log against office white-coat readings, order direct Apolipoprotein B (ApoB) and one-time genetic Lipoprotein(a), and decide if a CAC score or low-dose statin/ARB is warranted."
2. In-Office Medicare CPT Procedures to Verify Before Booking
CPT 93306 In-Office Transthoracic Echocardiogram with Doppler
Assesses left ventricular wall thickness and valve function directly in the cardiology suite.
CPT 93000 12-Lead Electrocardiogram (ECG) with Interpretation
Baseline rhythm and conduction screen prior to antihypertensive titration.
3. Exact Blood & Diagnostic Labs to Request on Your Order Sheet
✓Direct Apolipoprotein B (ApoB target < 80 mg/dL) + One-Time Lipoprotein(a) [Lp(a) in nmol/L]
✓High-Sensitivity C-Reactive Protein (hs-CRP < 1.0 mg/L)
1. Your 10-Second Opening Script (Read Verbatim Before the 11-Second Interruption)
"Even though my hemoglobin is normal, my Serum Ferritin is [X] ng/mL and I am experiencing persistent fatigue and hair shedding. Can we check a fasting Iron Panel with Transferrin Saturation (TSAT), rule out celiac/GI malabsorption, and target a Ferritin above 50–75 ng/mL?"
2. In-Office Medicare CPT Procedures to Verify Before Booking
1. Your 10-Second Opening Script (Read Verbatim Before the 11-Second Interruption)
"I have had [reflux / bloating / unexplained low ferritin] for [X] months. Today I want to distinguish upper GI mucosal issues from functional motility, review a step-down plan so I am not stuck on a PPI indefinitely, and verify whether you perform diagnostic EGD (CPT 43239) or colonoscopy (CPT 45385) at an ambulatory center."
2. In-Office Medicare CPT Procedures to Verify Before Booking
CPT 45385 Colonoscopy with Lesion Removal by Snare Technique
High annual CPT 45385 volume (>300/yr) correlates with higher adenoma detection rates and safer polypectomy.
CPT 43239 Upper GI Endoscopy (EGD) with Targeted Mucosal Biopsy
Rules out Barrett esophagus, H. pylori gastritis, and duodenal celiac villous atrophy.
3. Exact Blood & Diagnostic Labs to Request on Your Order Sheet
✓H. pylori Stool Antigen or Urea Breath Test (must be off PPIs for 14 days prior)
✓Celiac Serology (tTG-IgA + Total Serum IgA while still eating gluten)
4. Day-1 Pre-Appointment Rule
Always request an Ambulatory Surgery Center (ASC) facility quote rather than a hospital outpatient department (HOPD) for endoscopy/colonoscopy to save $1,200–$2,400 in facility fees.
Companion Clinical Evidence Reviews • PubMed & Federal Audits
Deep-Dive Research Breakdowns Related to Urolithin A (Mitopure Postbiotic)
Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial
This monograph is deterministically synthesized by the dotMD Clinical & Price Intelligence Desk from primary U.S. federal registries (FDA DailyMed SPL, NIH Office of Dietary Supplements, NIH DSLD v9, CMS Medicaid NADAC, CMS Medicare Part B, and NCBI PubMed MEDLINE). It is provided strictly for educational and health-literacy purposes and does not establish a doctor-patient relationship. Never start, stop, or alter a prescription medication or clinical treatment plan without consulting your licensed physician or pharmacist.
The Human Side • Pseudonymous Patient Logs & Peer Forum
Real-World Experiences & Questions on Urolithin A (Mitopure Postbiotic)
Compare structured “What Worked For Me” dosing logs and pseudonymous @Handle discussions in the Gut Health, Acid Reflux, Micronutrient Labs & Longevity space.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
DotMD Unified Community Space • Multi-Tagged FeedGut Health, Acid Reflux, Micronutrient Labs & Longevity
Every-other-day Iron Bisglycinate for ferritin > 50 ng/mL, tapering off Omeprazole without acid rebound, Vitamin D3 + K2 + Magnesium meal timing, and Psyllium fiber.
Showing active threads from Gut Health, Acid Reflux, Micronutrient Labs & Longevity
“People Like Me” Cohort Filter (Zero-PHI)
Filter Urolithin A (Mitopure Postbiotic) community Q&As, structured “What Worked For Me” reports, and dosage logs by age, sex, and duration.
Structured "What Worked For Me"@FerritinClimb_PA • 30–44F • Iron Bisglycinate 28 mg QOD • Week 16
109 helpful • 3 replies
Ferritin stuck under 20 ng/mL with hair shedding and exhaustion: did switching to every-other-day Iron Bisglycinate + Vitamin C work better than daily iron?
Pinned FDA / PubMed Clinical Context • Siriporn Wattana — Literature & Label Auditor
Randomized metabolic absorption trials in Lancet Haematology (Stoffel et al., PMID 29032957) proved that alternate-day oral iron dosing results in 34%–50% higher fractional iron absorption and significantly lower GI side effects than consecutive daily dosing because serum hepcidin returns to baseline after 48 hours. AGA guidelines use a ferritin cutoff of 45 ng/mL for iron deficiency.
My hemoglobin was normal (12.8 g/dL), so for years I was told I wasn't anemic—until a dermatologist ordered a Serum Ferritin test for my diffuse hair shedding and cold hands, and it came back at 12 ng/mL! When I tried taking standard ferrous sulfate 65 mg every single day, it tore up my stomach and caused awful constipation.
After reading about the ETH Zurich hepcidin studies showing that an oral iron dose spikes liver hepcidin for 24 hours (blocking the next day's dose and leaving unabsorbed iron to irritate the gut), I switched to 28 mg elemental Ferrochel Iron Bisglycinate taken every OTHER morning (Mon/Wed/Fri/Sun) on an empty stomach with 250 mg Vitamin C, waiting 90 minutes before coffee or calcium. Zero stomach cramps, and my ferritin climbed from 12 → 31 ng/mL at week 6 → 58 ng/mL at week 14! What ferritin number finally stopped your hair shedding and fatigue?
@ThyroidMorning_CA • 30–44F • Iron Bisglycinate QOD • Week 24
Alternate-day Iron Bisglycinate is the only iron I've ever been able to tolerate! Just remember if you take morning Levothyroxine, you MUST separate iron by at least 4 hours (I take thyroid at 6 AM and iron at 11 AM before lunch on M/W/F).
My hair shedding didn't slow down until my ferritin crossed 50 ng/mL, and my running endurance came back right around 45 ng/mL. Keep coffee and black tea at least an hour away from your iron pill—tannins cut absorption by more than half!
@BlueRidgeMom3 • 30–44F • Iron Bisglycinate 28 mg + Vit C • Week 16
Also rescued my restless legs at night! Once my ferritin went from 15 to 52 ng/mL, the evening leg twitching stopped completely.
Structured "What Worked For Me"@NorthWoodsLabs_WI • 45–59M • D3 4,000 IU + K2 + Mag • Week 14
97 helpful • 2 replies
Taking Vitamin D3 with K2 (MK-7) and Magnesium: how much did your 25(OH)D blood test actually go up after 12 weeks when taken with a fat-containing meal?
Pinned FDA / PubMed Clinical Context • Karim El-Sayed — Literature & Label Auditor
A clinical study in the Journal of Bone and Mineral Research (Dawson-Hughes et al., PMID 25441954) showed that taking Vitamin D3 with the largest fat-containing meal of the day increased serum 25(OH)D levels by an average of 50% compared to fasting intake. Note: Patients on Warfarin (Coumadin) must NOT take Vitamin K2 supplements, as K2 directly antagonizes warfarin anticoagulation.
My winter 25-hydroxyvitamin D lab came back at 17 ng/mL (deficient), even though I was taking a dry 2,000 IU tablet with my black coffee in the morning! I learned two critical absorption rules here: first, Vitamin D3 is fat-soluble, so taking a dry tablet on an empty stomach wastes almost 35–50% of the dose; second, the liver and kidney enzymes that convert D3 into active calcitriol are 100% magnesium-dependent.
I switched to an olive-oil softgel of 4,000 IU Vitamin D3 + 100 mcg Vitamin K2 (all-trans MK-7) taken right with dinner (salmon/avocado/olive oil), plus 200 mg elemental Magnesium Glycinate at night. My 12-week retest jumped from 17 ng/mL to 46 ng/mL while my serum calcium stayed right in the middle of normal! What daily dose and meal timing got your 25(OH)D into the 35–50 ng/mL sweet spot?
My doctor originally prescribed weekly 50,000 IU prescription Vitamin D2 (ergocalciferol), which barely moved my level from 19 to 26 ng/mL. Switching to daily 4,000 IU D3 (cholecalciferol) in oil with dinner brought me to 44 ng/mL in 10 weeks, and now 2,000 IU/day maintains it.
Fixing my Vitamin D from 18 to 44 ng/mL also completely resolved the mild leg achiness I used to get from my statin and improved my winter mood.
Community Discussion@RefluxReset_MA • 45–59M • PPI Taper → Famotidine Bridge • Week 12
95 helpful • 2 replies
Tried stopping Omeprazole or Pantoprazole 40 mg cold turkey and got hit with ferocious acid rebound at Day 5—how did you taper off successfully?
Pinned FDA / PubMed Clinical Context • Rohan Deshmukh — Literature & Label Auditor
American Gastroenterological Association (AGA) Clinical Practice Updates state that Rebound Acid Hypersecretion (RAHS) occurs in up to 40% of patients stopping long-term PPIs abruptly due to gastrin-driven enterochromaffin-like (ECL) cell hyperplasia, typically peaking 1–3 weeks post-discontinuation. Patients with Barrett's esophagus, severe Los Angeles Grade C/D esophagitis, or GI bleed risk should NOT discontinue PPIs without gastroenterologist supervision.
I was put on Omeprazole 40 mg during a stressful year and stayed on it for 18 months without having Barrett's esophagus or erosive esophagitis. When I tried stopping cold turkey last spring, days 4 through 10 brought worse burning acid in my throat than I ever had before starting the pill!
My gastroenterologist explained that long-term PPIs elevate gastrin, which causes the stomach's parietal and ECL cells to hypertrophy—so if you quit abruptly, all those extra acid pumps turn on at once (rebound acid hypersecretion). This time we did a slow 6-week taper: stepped down from 40 mg to 20 mg daily for 2 weeks, then 20 mg every other morning (using Famotidine 20 mg on the off-days and a sodium alginate raft after dinner), and raised the head of my bed 6 inches. I've been completely PPI-free for two months now! What taper schedule worked for you?
Using a sodium alginate suspension (Gaviscon Advance style with kelp alginate) right after dinner and before bed forms a physical foam raft on top of the stomach contents—that was the bridge that got me through weeks 2 and 3 of the taper.
@LabDetective_OR • 45–59F • Off PPI after 3 yrs • Week 24
Stopping eating 3 hours before lying down and sleeping on my left side (which keeps the stomach junction above the acid pool anatomically) made more difference than any pill once I finished the Famotidine step-down.
Has anyone tracked their LDL/ApoB and post-meal glucose before and after adding 10g/day of Psyllium Husk (and how do you space it from your medications)?
Pinned FDA / PubMed Clinical Context • Siriporn Wattana — Literature & Label Auditor
A meta-analysis of 28 randomized controlled trials in The American Journal of Clinical Nutrition (Jovanovski et al., PMID 30239559) confirmed that ~10 g/day of psyllium viscous fiber reduces LDL-C by 13 mg/dL and ApoB by ~6.5% by trapping bile acids in the gut lumen. Always consume with at least 8–12 oz of water and separate oral medications (especially Levothyroxine, Digoxin, and Metformin) by 1–2 hours.
My LDL was 128 mg/dL and my post-lunch glucose on my CGM used to spike 45 points whenever I ate rice or sourdough bread. Before starting a prescription, my internist suggested a 12-week trial of 5 grams of whole psyllium husk stirred into 12 oz of water 10 minutes before lunch and 5 grams before dinner (starting with 1 teaspoon for the first week so I didn't get bloated).
Because viscous soluble fiber forms a gel that binds bile acids in the small intestine—forcing the liver to pull LDL cholesterol out of the bloodstream to make new bile—my 12-week LDL dropped by 19 mg/dL (down to 109 mg/dL) and my post-meal glucose spikes dropped in half! Just make sure to take prescription meds at least 1–2 hours away from psyllium. What brand (lead-tested whole husk vs. powder) and routine works best for you?
Psyllium husk is like natural Ezetimibe for bile acids! Adding 5g before dinner on top of my low-dose statin shaved another 14 points off my ApoB. Also check third-party testing (ConsumerLab) to pick low-lead organic whole husks.
Drinking it right after stirring—before it turns into thick jelly in the glass—and chasing it with half a glass of plain water makes it super easy to drink.
