Recent publications, longitudinal cohorts, and clinical practice updates from The New England Journal of Medicine, The Lancet, JAMA, BMJ, and Nature Medicine. Every study summary reports the trial design, participant sample size (N), primary outcome highlight, and direct link to the formal NCBI PubMed or federal record.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
New England Journal of Medicine, Volume 395, Issue 18 , Page 1861-1863, November 5, 2026.
In Reply We thank Dr Verbruggen and colleagues for their thoughtful comments on the GASTRIC-PICU randomized clinical trial.
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
This Medical News article discusses the reasons behind the burgeoning black market for 2 unapproved GLP-1 weight loss drugs and the potential risks associated with their use.
Nature Medicine, Published online: 03 November 2026; doi:10.1038/s41591-026-04792-x Publisher Correction: Molecular predictors of minimal residual disease in newly diagnosed multiple myeloma treated with quadruplet therapy
Nature Medicine, Published online: 03 November 2026; doi:10.1038/s41591-026-04737-4 In this study, the gut, oral, urinary and vaginocervical microbiomes of women receiving menopausal hormone therapy were studied over 6 months, shedding light on how system meta
Nature Medicine, Published online: 03 November 2026; doi:10.1038/s41591-026-04686-y In a phase 1b study that included an open-label and randomized-controlled cohorts of allogeneic hematopoietic cell transplantation recipients, treatment with the investigationa
There’s a simple model of general practice where a patient with newly occurring symptoms seeks help from a doctor. The doctor arrives at a diagnosis and then reassures, treats, or refers the patient on for hospital care. Sometimes this is what happens, but inc
Nature Medicine, Published online: 03 November 2026; doi:10.1038/s41591-026-04786-9 Author Correction: In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial
The median age of adult people with diagnosed HIV in the US is projected to increase from 51 years to 61 years by 2040, according to a study published in JAMA Network Open.
A clinical tool kit published in Obstetrics & Gynecology outlines hormonal options for perimenopause care.
A recent college drinking trend known as the “blackout rage gallon” (BORG) may promote high-intensity drinking and alcohol-related harm, a study suggests.
The BMJ covered the OpenAI hack of an Australian government health website1 and its potential implications.2 But the scale and severity of the implications do not seem to be fully appreciated. This event presents some simple truths, but it’s unclear if we can
Consuming several servings of whole grains each day may lower certain risk factors for cardiovascular disease, according to a systematic review and meta-analysis published in the European Heart Journal.
To the Editor The GASTRIC-PICU landmark trial addressed a long-standing, weakly evidenced practice in pediatric intensive care. The case for deimplementing routine gastric residual volume (GRV) assessment will likely change bedside care. We raise 2 points that
A new study to examine levels of so called “forever chemicals” in the UK population and their potential effects on human health will be launched by health officials.The UK Health Security Agency (UKHSA) will look at blood and urine samples to examine populatio
Doctors struck off Italy’s medical register during the covid-19 pandemic because of their antivaccine views could soon be allowed to apply for reinstatement.1On 27 October, one of the country’s political bodies, the Italian Chamber of Deputies, approved the mo
The Belém Gender Action Plan on gender equity in climate governance and the Belém Health Action Plan on climate resilient health systems were adopted at COP30 in 2025. 12 Taken together, they explicitly state that climate related risks for health systems, heal
bmj;395/nov03_9/e100836/F1F1f1Malcolm MacCulloch was a forensic psychiatrist who had a fascinating but at times controversial career, by modern considerations. As a young researcher at Crumpsall Hospital in Manchester he became interested in human sexuality an
bmj;395/nov03_10/e100837/F1F1f1Hassan Burhan used to do his ward round as a respiratory consultant at Royal Liverpool University Hospital in a necktie and sandals, cracking jokes with patients, cleaners, and hospital porters. Burhan was on first name terms wit
The US Food and Drug Administration (FDA) authorized the first wearable device that continuously monitors ketone levels in people with type 1 diabetes.
An early warning system to spot deteriorating children will be rolled out across England’s emergency departments this winter.Called the Paediatric Early Warning System (PEWS), this requires staff to measure, record, and assess children’s vital signs, before as
bmj;395/nov03_13/e101314/F1F1f1Xinhua/AlamyThe graves of people who have died from Ebola virus disease continue to spread around the outskirts of Bunia, the capital of the Democratic Republic of the Congo’s Ituri province. The outbreak has now claimed almost 5
Living in a disadvantaged neighborhood was associated with adverse brain health, a retrospective study found.
Nature Medicine, Published online: 03 November 2026; doi:10.1038/s41591-026-04743-6 As presented at the Society for Immunotherapy of Cancer 2026 Annual Meeting, in a non-prespecified pooled analysis of two trials, amsokigene autoleucel, an autologous tumor-inf
This Medical News article discusses the increase in routine cannabis use among younger adults, which corresponds with a decrease in regular alcohol use.
bmj;395/nov03_8/e100835/F1F1f1An estimated 1000 people die of rabies every year in Pakistan, the vast majority children. Naseem Salahuddin, professor of infectious diseases, tried to tackle this scourge through her landmark Rabies Free Pakistan initiative. She
Nature Medicine, Published online: 02 November 2026; doi:10.1038/s41591-026-04729-4 Analyses of the Global Burden of Disease study reported 887,000 new cases and 369,000 deaths from cervical cancer worldwide in 2023, which are forecasted to rise by 2050.
Nature Medicine, Published online: 02 November 2026; doi:10.1038/s41591-026-04739-2 In the STOP-V1 and STOP-V2 trials, povorcitinib (an oral JAK1 inhibitor) was superior to placebo in improvement in F-VASI75 score in individuals with nonsegmental vitiligo.
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of manufactured chemicals that have been in widespread use for more than 70 years in applications such as waterproofing, firefighting, non-stick cookware, and lubrication.1 PFAS are thermally and
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
