Recent publications, longitudinal cohorts, and clinical practice updates from The New England Journal of Medicine, The Lancet, JAMA, BMJ, and Nature Medicine. Every study summary reports the trial design, participant sample size (N), primary outcome highlight, and direct link to the formal NCBI PubMed or federal record.
The Plain-English Receipt: Only 1.2% of prediabetic adults on Tirzepatide progressed to Type 2 diabetes over 3.4 years vs. 19.3% on placebo (Absolute Risk Reduction = 18.1% • Number Needed to Treat = 6).
A consultant transplant surgeon who admitted to engaging in sadomasochism in his private life has won a High Court ruling lifting interim conditions on his practice.These conditions included a bar on carrying out face-to-face consultations with female patients
McNamara’s call for coordinated international regulatory action by governments on hyperscale data centres owing to health and environmental threats is timely.1 Precaution is needed. The costs of hyperscale data centres can damage economies, communities, public
More than 3000 young people under 18 were admitted to hospital with chickenpox in England last year, new data from the UK Health Security Agency (UKHSA) show.1Children aged 5 and under bore the brunt of the illness, accounting for over 70% of all clinical chic
Sounds Fe-nomenalNot quite. According to a growing number of TikTok influencers, a wan pallor, dry skin, dark eyebags, and thinning hair aren’t the consequence of stress or sleepless nights, but proof that you suffer from low iron levels.Ferreting out “ferriti
Andy Burnham should make tackling England’s obesity epidemic his “clear, personal mission” because current plans to redress the problem are “doomed to fail,” MPs warned.A “moonshot to end the obesity epidemic” was promised in the 2025 10 Year Health Plan1 but
Medical jobs in illegal Israeli settlements in the West Bank were advertised to UK doctors in leaflets distributed at a London jobs fair, in what medical charities have condemned as an “obscene” enterprise.It comes just weeks after the UK government toughened
Nature Medicine, Published online: 02 November 2026; doi:10.1038/s41591-026-04710-1 In the phase 2 UNICORN trial, a short course of neoadjuvant botensilimab and balstilimab achieved the primary endpoint of pathological major response rate in patients with pMMR
With an opportunity to overturn Republican control of Congress, Democrats hope to win voters’ support by focusing on cuts to health-care programmes. Susan Jaffe reports from Washington, DC.
Many men are failing to thrive. Shorter life expectancies for men than for woman first emerged in the 19th century and the gap has continued to widen (albeit with geographical variations). Men have a higher burden of illness: global disability-adjusted life-ye
A patient in France has died from the infection, which normally affects cattle. Virologists say the wider risk to public health is low. Marianne Guenot reports.
Afghanistan has reported twice as many polio cases than in 2025, prompting concern over the Taliban's vaccination policies. Samaan Lateef reports.
The authors of The Lancet's Series on men's health1–3 provide a genuinely world-scale picture of the issues. Their approach links biological with social process, and emphasises intersectional perspectives. The Series papers offer valuable case studies, and a s
“We know a lot about male health. We don’t know a lot about men's health”, says Derek Griffith, who is one of the authors of a new Lancet Series on men's health. “Male health is about male bodies and hormones. Men's health is more holistic and comprehensive an
The Lancet Countdown on health and climate change celebrated its tenth anniversary this week. The Countdown was preceded by two Lancet Commissions that sought to mobilise multiple disciplines within universities to address the climate crisis. The first Commiss
Paediatric acute respiratory distress syndrome (PARDS) is a common, severe manifestation of direct or indirect lung injury in children. Management focuses on the careful implementation of lung protective strategies with high-frequency oscillatory ventilation (
Non-invasive tests (NITs) are central to clinical decision making in metabolic dysfunction-associated steatotic liver disease, including risk stratification, treatment decisions, referral pathways, and recruitment into clinical trials.1 As pharmacological trea
Jim Catto, co-leading author of the Lancet Series on men's health, was reluctant to be the subject of a profile, insisting it is more important to highlight what he is trying to accomplish: tackling the inequalities in men's health. The patients he cares for c
Rupsa Chakraborty has won an international writing award for her investigation into gender discrimination affecting organ donation in India, which was published in The BMJ.Chakraborty, a freelance investigative journalist and public health researcher at the Lo
Patients waiting for specialist care were dropped off the electronic referral service (e-RS) without warning, a national safety watchdog has warned.A Health Services Safety Investigations Body (HSSIB) report earlier this month found that from February to July
Ministers have scrapped plans to abolish Healthwatch England and local Healthwatch groups, after pushback from health leaders and organisations.Launched in 2012, Healthwatch functions as a statutory independent voice for patients, helping the public hold the N
bmj;395/oct30_11/e101174/F1F1f1Rama (known to many of his UK colleagues as “Ron”) was born in Bihar, India, in 1949. His father was an acclaimed general surgeon and, after Rama’s mother died suddenly, he was raised by his beloved second mother, a nurse. The el
Nature Medicine, Published online: 30 October 2026; doi:10.1038/s41591-026-04722-x A multidisciplinary group of policymakers and researchers discusses the impacts of climate change on malaria in the Asia Pacific, identifies gaps in national adaptation strategi
bmj;395/oct30_10/e101173/F1F1f1Edward Peter Lawrence was born in 1930 in eastern India to parents working in the coalmining industry near Kolkata. After completing school in Darjeeling he came to England in 1948 to study at King’s College Cambridge, where he r
“Questions must be asked” about the lack of warning before hundreds of practice websites went offline after an online provider entered administration, GP leaders say.They have also questioned why there doesn’t seem to be a coordinated national contingency plan
An “ethical policy” that prevented assisted dying campaign groups from hosting events at the Royal College of General Practitioners will be “reviewed and amended,” the college pledged today.This reversal comes after the campaign group Dignity in Dying was prev
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04723-w A 5-year secondary analysis of the phase 2 PHERGain trial supports the clinical utility of a PET-guided adaptive strategy for treatment de-escalation in HER2-positive early brea
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04721-y A high-resolution snRNA-seq atlas of 189 colorectal tumors from patients aged 20–90+ years uncovers age-associated features of colorectal cancer.
Nature Medicine, Published online: 29 October 2026; doi:10.1038/d41591-026-00056-w Researchers developed a digital twin framework to safely evaluate the effects of drugs on the immune system and time to labor, which could enable personalized interventions to p
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04655-5 A multimodal vision language foundation model, EVLF-FM, integrates extensive clinical data and advanced training techniques, achieving superior diagnostic accuracy and explainab
Nature Medicine, Published online: 29 October 2026; doi:10.1038/d41591-026-00055-x Preclinical analysis and a phase 1 trial support VG-3927 as a promising drug candidate for Alzheimer’s disease, demonstrating successful penetration of the central nervous syste
Traditional health headlines often exaggerate findings by reporting only Relative Risk Reduction—for example, claiming a drug cuts risk by 50% when the event rate dropped from 2% to 1% (an Absolute Risk Reduction of just 1.0 percentage point, meaning 100 patients must take the drug for 1 person to benefit, or NNT = 100). On dotMD, every flagship study breakdown reports both Relative Risk and Absolute Risk alongside the exact sample size (N) and trial duration.
Every study on dotMD displays its exact Study Design Tier at the top of the card (Phase 3 Randomized Trial, Randomized Controlled Trial, Meta-Analysis & Systematic Review, Multi-Trial Clinical Evidence Synthesis, Journal Watch Cohort, or FDA Safety Alert) along with the human participant count (N). Preclinical mouse or cell-culture data is never presented as human clinical proof.
Arbitrary 0-to-100 rigor scores obscure what actually makes a study trustworthy. Instead of synthetic scores, dotMD surfaces the verifiable primary evidence signals: exact NCBI PubMed IDs (PMID), ClinicalTrials.gov registration numbers (NCT), double-blind vs. crossover design, sample size (N), p-values / Hazard Ratios, and study limitations.
Medical research is only useful if you can act on it safely with your clinician. Every flagship research synthesis links directly to the parent Condition diagnostic cutoff guide, the Medication FDA DailyMed & CMS NADAC wholesale price ledger, the Supplement elemental weight decoder, and our High-CPT-Volume Specialist Directory.
